Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 7/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6621607 | 0.87 | KMT2A (0.51) | KMT2AHPGDALOX12MEN1CYP1A2 | |
| SCHEMBL6621943 | 0.83 | KMT2A (0.47) | KMT2AHPGDALOX12MEN1CYP1A2 | |
| SCHEMBL6241284 | 0.77 | KMT2A (0.58) | KMT2AHPGDALOX12MEN1CYP1A2 | |
| SCHEMBL6619847 | 0.72 | KMT2A (0.43) | KMT2AHPGDMEN1CYP1A2CYP2D6 | |
| SCHEMBL6617115 | 0.72 | GAA (0.49) | KMT2AHPGDALOX12MEN1CYP1A2 | |
| SCHEMBL6619330 | 0.71 | CETP (0.49) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6624493 | 0.70 | KMT2A (0.47) | KMT2AHPGDMEN1CYP1A2ALDH1A1 | |
| SCHEMBL6619658 | 0.70 | CA12 (0.42) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6619609 | 0.69 | CYP1A2 (0.47) | KMT2AHPGDMEN1CYP1A2CYP3A4 | |
| SCHEMBL6622668 | 0.69 | CA12 (0.40) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828446-B2 | Sulfides such as N-(2-(((6- chloro-1,3-benzodioxol-5-yl)methyl )thio)phenyl)thiophene-2-carboxamide used for controlling metabolism of lipids and prophylaxis of diabetes, Alzheimers disease, atherosclerosis, dyslipidemia and genetic disorders | PHARMACIA CORPORATION | 2004-12-07 | — | — | US | claimed |
| EP-1463726-A2 | AROMATIC THIOETHER LIVER X-RECEPTOR MODULATORS | Pharmacia Corporation (US) | 2004-10-06 | — | — | EP | claimed |
| US-20030207898-A1 | Aromatic thioether liver X-receptor modulators | PHARMACIA CORPORATION | 2003-11-06 | — | — | US | claimed |
| WO-2003059874-A2 | AROMATIC THIOETHER LIVER X-RECEPTOR MODULATORS | PHARMACIA CORPORATION (US) | 2003-07-24 | — | — | WO | claimed |
| US-6828446-B2 | Sulfides such as N-(2-(((6- chloro-1,3-benzodioxol-5-yl)methyl )thio)phenyl)thiophene-2-carboxamide used for controlling metabolism of lipids and prophylaxis of diabetes, Alzheimers disease, atherosclerosis, dyslipidemia and genetic disorders | PHARMACIA CORPORATION | 2004-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207898-A1 | Aromatic thioether liver X-receptor modulators | NR1H2, NR1H3, NR1H4 | KMT2A 1719/4885HPGD 2179/4885ALOX12 1240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.