SCHEMBL6622301

SCHEMBL6622301

NC1CCc2c(-c3ccccc3)[nH]c3cc(F)cc1c23

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 10/20 0.41
PARP2 Q9UGN5 7/20 0.41
KCNH2 Q12809 3/20 0.37
HTR2A P28223 2/20 0.37
HTR2C P28335 2/20 0.37
DYRK3 O43781 1/20 0.36
TNKS O95271 1/20 0.36
PGR P06401 1/20 0.36
CDK1 P06493 1/20 0.36
ADRB1 P08588 1/20 0.36
POLA1 P09884 1/20 0.36
PIM1 P11309 1/20 0.36
SLC6A2 P23975 1/20 0.36
ADRA1A P35348 1/20 0.36
PTGS2 P35354 1/20 0.36
CDK16 Q00536 1/20 0.36
PDE4D Q08499 1/20 0.36
DYRK1A Q13627 1/20 0.36
PARP15 Q460N3 1/20 0.36
PARP14 Q460N5 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6625314 0.85 PARP1 (0.36) PARP1HTR2A
SCHEMBL6624938 0.85 PARP1 (0.36) PARP1PARP2KCNH2HTR2ACDK1
SCHEMBL6626187 0.81 PDE5A (0.39) PARP1
SCHEMBL6622880 0.81 PARP1 (0.48) PARP1KCNH2HTR2AHTR2C
Hydrochloric Acid SCHEMBL6626987 0.80 PARP1 (0.47) PARP1KCNH2HTR2AHTR2C
SCHEMBL6625155 0.78 KDM4E (0.39) PARP1PARP2KCNH2HTR2CPTGS2
SCHEMBL6622924 0.75 HTR2A (0.38) PARP1KCNH2HTR2AHTR2CCNR1
SCHEMBL6624818 0.75 PARP1 (0.40) PARP1KCNH2HTR2AHTR2CCNR1
SCHEMBL6622919 0.71 PARP1 (0.50) PARP1PARP2KCNH2DYRK3TNKS
SCHEMBL6623975 0.71 PARP1 (0.39) PARP1HTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0858996-B1 NERVE CELL PROTECTIVE AGENTS MOCHIDA PHARM CO LTD (JP) 2004-10-27 EP disclosed
US-6040331-A Nerve cell protective agents MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-03-21 US disclosed
EP-0858996-A1 NERVE CELL PROTECTIVE AGENTS MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1998-08-19 EP disclosed