Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.64 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.64 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | AKT2 | P31751 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | FRK | P42685 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622898 | 1.00 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6636543 | 0.93 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6636545 | 0.93 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6619266 | 0.88 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6622012 | 0.86 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6622017 | 0.86 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6619647 | 0.86 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6619645 | 0.86 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6666766 | 0.85 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6666759 | 0.85 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485167-A1 | 1,2-DIHYDROPYRAZOL-3-ONES AS CYTOKINE MEDIATORS | The Procter & Gamble Company (US) | 2004-12-15 | — | — | EP | claimed |
| US-6677337-B2 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, INFLAMMATORY BOWEL DISEASE, CACHEXIA, SEPTIC SHOCK, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | THE PROCTER & GAMBLE COMPANY | 2004-01-13 | — | — | US | claimed |
| WO-2003080184-A1 | 1,2-DIHYDROPYRAZOL-3-ONES AS CYTOKINE MEDIATORS | THE PROCTER & GAMBLE COMPANY (US) | 2003-10-02 | — | — | WO | claimed |