Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032974 | 0.92 | EGFR (0.76) | EGFRERBB2SRCKDR | |
| SCHEMBL4033013 | 0.88 | EGFR (0.77) | EGFRERBB2 | |
| SCHEMBL4033583 | 0.85 | EGFR (0.64) | EGFRERBB2 | |
| SCHEMBL15643134 | 0.84 | EGFR (0.84) | EGFRERBB2SRCKDR | |
| SCHEMBL4032825 | 0.83 | EGFR (0.78) | EGFRERBB2SRC | |
| SCHEMBL4036145 | 0.83 | EGFR (0.65) | EGFRERBB2 | |
| SCHEMBL4034731 | 0.81 | EGFR (0.86) | EGFRERBB2SRCKDR | |
| SCHEMBL4038435 | 0.81 | EGFR (1.00) | EGFRSRCKDR | |
| SCHEMBL4036152 | 0.81 | EGFR (1.00) | EGFRSRCKDR | |
| SCHEMBL4033880 | 0.81 | EGFR (0.85) | EGFRERBB2SRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-A2 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040109-A2 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |