Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 3/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 2/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8605472 | 0.90 | PRCP (0.62) | PRCPCHRNB2CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL1072561 | 0.90 | PRCP (0.62) | PRCPCHRNB2CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL19996549 | 0.87 | PRCP (0.45) | PRCPCHRNB2CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL24072254 | 0.87 | PRCP (0.72) | PRCPGNAI3GNAO1GNAI1EPHX1 | |
| SCHEMBL18402567 | 0.87 | PRCP (0.72) | PRCPGNAI3GNAO1GNAI1EPHX1 | |
| SCHEMBL7379054 | 0.87 | PRCP (0.72) | PRCPGNAI3GNAO1GNAI1EPHX1 | |
| SCHEMBL10681169 | 0.84 | PRCP (0.42) | PRCPCHRNB2CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL13500517 | 0.82 | PRCP (0.74) | PRCPCHRNB2CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL6361143 | 0.82 | PRCP (0.74) | PRCPCHRNB2CHRNA7CHRNA4CHRNB4 | |
| SCHEMBL3289136 | 0.77 | PRCP (0.77) | PRCPCHRNB2CHRNA7CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389194-A2 | INHIBITORS OF BACE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002088101-A2 | INHIBITORS OF BACE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-11-07 | — | — | WO | disclosed |