Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033516 | 0.82 | SYK (0.39) | SYKPIK3CAPIK3CDPIK3CBLRRK2 | |
| SCHEMBL6626794 | 0.78 | SYK (0.34) | SYKPIK3CAPIK3CDPIK3CBLRRK2 | |
| SCHEMBL18128950 | 0.78 | PIK3CD (0.39) | SYKPIK3CAPIK3CDPIK3CBLRRK2 | |
| SCHEMBL18128959 | 0.78 | SYK (0.42) | SYKPIK3CAPIK3CDPIK3CBLRRK2 | |
| SCHEMBL1015994 | 0.75 | EGFR (0.48) | LRRK2 | |
| SCHEMBL16747780 | 0.75 | PIK3CD (0.39) | SYKPIK3CAPIK3CDPIK3CBLRRK2 | |
| SCHEMBL3193077 | 0.74 | LRRK2 (0.41) | SYKPIK3CAPIK3CDPIK3CBLRRK2 | |
| SCHEMBL3275587 | 0.74 | LRRK2 (0.41) | SYKPIK3CAPIK3CDPIK3CBLRRK2 | |
| SCHEMBL21187302 | 0.74 | PIK3CA (0.49) | SYKPIK3CAPIK3CDPIK3CB | |
| SCHEMBL21177857 | 0.74 | PIK3CA (0.49) | SYKPIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-A2 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040109-A2 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |