Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.65 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587708 | 0.85 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DKDR | |
| SCHEMBL6589078 | 0.84 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6587900 | 0.84 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4701651 | 0.84 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6589991 | 0.84 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6587710 | 0.82 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6587423 | 0.82 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6586166 | 0.80 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DKDR | |
| SCHEMBL6585568 | 0.80 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6585199 | 0.80 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124829-B1 | TRICYCLIC PHTHALAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2004-08-04 | — | — | EP | disclosed |
| US-6525055-B1 | Allergic and inflammatory pathologies such as, for example, emphysema, chronic bronchitis, asthma and allergic rhinitis. | ZAMBON GROUP S.P.A. (IT) | 2003-02-25 | — | — | US | disclosed |