Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6291866 | 0.89 | GSK3B (0.50) | GSK3BF2RAB9ANR1H2NR1H3 | |
| SCHEMBL6288696 | 0.88 | GSK3B (0.43) | GSK3BLMNAF2RAB9ANR1H2 | |
| SCHEMBL6288538 | 0.87 | MAPT (0.43) | GSK3BLMNAF2RAB9AMAPT | |
| SCHEMBL6291373 | 0.85 | MAPT (0.46) | GSK3BLMNAF2RAB9AMAPT | |
| SCHEMBL6291831 | 0.82 | MAPT (0.48) | GSK3BLMNAMAPTTP53POLB | |
| SCHEMBL6288383 | 0.81 | MEN1 (0.44) | GSK3BLMNAMAPTKMT2ATSHR | |
| SCHEMBL6288572 | 0.79 | TSHR (0.46) | LMNARAB9AMAPTTP53KMT2A | |
| SCHEMBL6288568 | 0.79 | GSK3B (0.47) | GSK3BLMNARAB9AMAPTTSHR | |
| SCHEMBL5619875 | 0.68 | EGFR (0.45) | MAPTKMT2AMEN1GAA | |
| SCHEMBL5620144 | 0.64 | AHR (0.36) | GSK3BLMNARAB9ANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404677-A1 | IMIDAZOTRIAZINES FOR USE AS PHOSPHODIESTERASE INHIBITORS | Bayer HealthCare AG (DE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000693-A1 | IMIDAZOTRIAZINES FOR USE AS PHOSPHODIESTERASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2003-01-03 | — | — | WO | disclosed |