Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.49 |
| ▸ | FLT1 | P17948 | 12/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | VCP | P55072 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6302572 | 1.00 | EGFR (0.49) | EGFRFLT1KDRMETSYK | |
| SCHEMBL6302384 | 0.92 | FLT1 (0.51) | EGFRFLT1KDRMETSYK | |
| SCHEMBL6309330 | 0.92 | FLT1 (0.51) | EGFRFLT1KDRMETSYK | |
| SCHEMBL6302403 | 0.92 | FLT1 (0.51) | EGFRFLT1KDRMETSYK | |
| SCHEMBL6302480 | 0.90 | EGFR (0.49) | EGFRFLT1KDRMETSYK | |
| SCHEMBL6625751 | 0.90 | EGFR (0.49) | EGFRFLT1KDRMETSYK | |
| SCHEMBL6302469 | 0.90 | EGFR (0.49) | EGFRFLT1KDRMETSYK | |
| SCHEMBL6303870 | 0.90 | EGFR (0.49) | EGFRFLT1KDRMETSYK | |
| SCHEMBL6301850 | 0.90 | FLT1 (0.49) | EGFRFLT1KDRMETSYK | |
| SCHEMBL6301857 | 0.90 | FLT1 (0.49) | EGFRFLT1KDRMETSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1287001-B1 | THIOPHENE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PROD INC (US) | 2004-09-29 | — | — | EP | disclosed |