Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6626267 | 1.00 | TDP1 (0.47) | TDP1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6626270 | 1.00 | TDP1 (0.47) | TDP1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL30796029 | 1.00 | TDP1 (0.47) | TDP1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6626264 | 1.00 | TDP1 (0.47) | TDP1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6851568 | 0.94 | TDP1 (0.45) | TDP1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6851571 | 0.94 | TDP1 (0.45) | TDP1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6851565 | 0.94 | TDP1 (0.45) | TDP1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6626118 | 0.92 | TDP1 (0.47) | TDP1SMN1; SMN2LMNAKMT2AKCNQ3 | |
| SCHEMBL6626121 | 0.92 | TDP1 (0.47) | TDP1SMN1; SMN2LMNAKMT2AKCNQ3 | |
| SCHEMBL6626115 | 0.92 | TDP1 (0.47) | TDP1SMN1; SMN2LMNAKMT2AKCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392644-A1 | CINNAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002096858-A1 | CINNAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-12-05 | — | — | WO | disclosed |