Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 14/20 | 0.65 |
| ▸ | LPAR2 | Q9HBW0 | 8/20 | 0.65 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6630010 | 0.98 | LPAR3 (0.69) | LPAR3LPAR2LPAR1CYP3A4LPAR5 | |
| SCHEMBL6626611 | 0.93 | — | — | |
| SCHEMBL777957 | 0.84 | LPAR3 (0.68) | LPAR3LPAR2LPAR1CYP3A4LPAR5 | |
| SCHEMBL6628691 | 0.83 | — | — | |
| SCHEMBL17626478 | 0.82 | LPAR3 (0.65) | LPAR3LPAR2LPAR1CYP3A4LPAR5 | |
| SCHEMBL14497999 | 0.82 | LPAR3 (0.72) | LPAR3LPAR2LPAR1CYP3A4LPAR5 | |
| SCHEMBL14902016 | 0.82 | LPAR3 (0.72) | LPAR3LPAR2LPAR1CYP3A4LPAR5 | |
| SCHEMBL1083222 | 0.82 | LPAR3 (0.65) | LPAR3LPAR2LPAR1CYP3A4LPAR5 | |
| SCHEMBL14085392 | 0.82 | LPAR3 (0.72) | LPAR3LPAR2LPAR1CYP3A4LPAR5 | |
| SCHEMBL18025332 | 0.82 | LPAR3 (0.72) | LPAR3LPAR2LPAR1CYP3A4LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | claimed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | claimed |
| EP-1227098-B1 | TRIAZOLOPURINE DERIVATIVES, DRUG COMPOSITIONS CONTAINING THE SAME AND ADENOSINE A3 RECEPTOR AFFINITIVE AGENTS | OTSUKA PHARMA CO LTD (JP) | 2004-04-28 | — | — | EP | disclosed |
| US-6686343-B1 | Triazolopurine derivatives, pharmaceutical compositions containing the derivatives, and adenosine A3 receptor affinitive agents | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2004-02-03 | — | — | US | disclosed |
| EP-1227098-A1 | TRIAZOLOPURINE DERIVATIVES, DRUG COMPOSITIONS CONTAINING THE SAME AND ADENOSINE A3 RECEPTOR AFFINITIVE AGENTS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2002-07-31 | — | — | EP | disclosed |
| US-5519138-A | ANGIOTENSIN ANTAGONIST | DR. KARL THOMAE GMBH (DE) | 1996-05-21 | — | — | US | disclosed |
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |