Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.50 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.50 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932386 | 0.83 | HTR2C (0.53) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL31295228 | 0.80 | HTR2C (0.50) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL14336080 | 0.79 | HTR2C (0.57) | HTR2CP2RX4SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1766231 | 0.78 | HTR2C (0.60) | HTR2CP2RX4SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6629621 | 0.78 | HTR2C (0.45) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL3941416 | 0.77 | SMN1; SMN2 (0.57) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4431805 | 0.77 | HTR2C (0.72) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL6630038 | 0.77 | HTR2C (0.44) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL27578386 | 0.76 | HTR2C (0.59) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL25125018 | 0.76 | HTR2C (0.61) | HTR2CP2RX1P2RX3P2RX4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098897-B1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR STIMULATING NEURONAL GROWTH AND ELONGATION | AGOURON PHARMA (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6630472-B1 | Peptidyl-prolyl isomerase inhibitors | PFIZER INC | 2003-10-07 | — | — | US | disclosed |
| EP-1098897-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR STIMULATING NEURONAL GROWTH AND ELONGATION | AGOURON PHARMACEUTICALS, INC. (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004020-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR STIMULATING NEURONAL GROWTH AND ELONGATION | AGOURON PHARMACEUTICALS, INC. (US) | 2000-01-27 | — | — | WO | disclosed |