Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.39 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6478129 | 0.89 | GSK3B (0.59) | GSK3BCDK2CDK1CYP1A2FLT4 | |
| SCHEMBL6478442 | 0.85 | GSK3B (0.47) | GSK3BCDK2CDK1CYP1A2FLT4 | |
| SCHEMBL1377394 | 0.75 | GSK3B (0.58) | GSK3BCDK2CDK1CYP1A2FLT4 | |
| SCHEMBL1461503 | 0.73 | GSK3B (0.59) | GSK3BCDK2CDK1CYP1A2FLT4 | |
| SCHEMBL6478219 | 0.69 | GSK3B (0.58) | GSK3BCDK2CDK1CYP1A2CDK5 | |
| SCHEMBL1461697 | 0.67 | GSK3B (0.82) | GSK3BCDK2CDK1CYP1A2FLT4 | |
| SCHEMBL1462440 | 0.66 | GSK3B (1.00) | GSK3BCYP1A2 | |
| SCHEMBL6477960 | 0.66 | GSK3B (0.54) | GSK3BCDK2CDK1CYP1A2CDK5 | |
| SCHEMBL1461369 | 0.66 | GSK3B (0.55) | GSK3BCDK2CDK1CYP1A2FLT4 | |
| SCHEMBL6490286 | 0.64 | GSK3B (1.00) | GSK3BCYP1A2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487804-A2 | AMINOINDAZOLE DERIVATIVES AS PROTEIN-KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078403-A2 | DERIVES D’AMINOINDAZOLES COMME INHIBITEURS DE PROTEINE-KINASE | AVENTIS PHARMA S.A. (FR) | 2003-09-25 | — | — | WO | disclosed |