Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 8/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629769 | 1.00 | CDK5 (0.45) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5341550 | 0.94 | CDK5 (0.49) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5348521 | 0.91 | CDK5 (0.49) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5349504 | 0.88 | CDK5 (0.39) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5345327 | 0.88 | CDK5 (0.40) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5346428 | 0.87 | CDK5 (0.33) | CDK5CDK5R1RAB9ASLC6A3SLC6A2 | |
| SCHEMBL5348169 | 0.87 | CDK5 (0.41) | CDK5CDK5R1RAB9ASLC6A3SLC6A2 | |
| SCHEMBL5353323 | 0.86 | P2RY1 (0.37) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5346938 | 0.86 | CDK5 (0.47) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5338114 | 0.86 | BTK (0.36) | CDK5CDK5R1RAB9ASLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483263-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-12-08 | — | — | EP | claimed |
| WO-2003070727-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-08-28 | — | — | WO | claimed |
| EP-1483263-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003070727-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-08-28 | — | — | WO | disclosed |