Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.34 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | PDE6C | P51160 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6630131 | 0.81 | PDE5A (0.50) | PDE5AKDM4EALDH1A1KMT2APDE4A | |
| SCHEMBL6629253 | 0.72 | PDE5A (0.65) | PDE5ABRD4KDM4EALDH1A1KMT2A | |
| SCHEMBL6630690 | 0.72 | KMT2A (0.43) | PDE5AKDM4EALDH1A1KMT2APDE4A | |
| SCHEMBL6631120 | 0.71 | PDE5A (0.60) | PDE5AKDM4EKMT2APDE6C | |
| SCHEMBL6806204 | 0.71 | POLB (0.38) | SLC16A3SLC16A1ALDH1A1MEN1KMT2A | |
| SCHEMBL6630001 | 0.71 | PDE5A (0.56) | PDE5AKDM4EKMT2APDE4APDE4B | |
| SCHEMBL6811716 | 0.70 | PDE5A (0.53) | PDE5AKDM4EKMT2APDE4APDE4B | |
| SCHEMBL6630455 | 0.67 | KMT2A (0.45) | PDE5ABRD4KDM4EALDH1A1KMT2A | |
| SCHEMBL6802097 | 0.67 | PDE5A (0.36) | PDE5ASLC16A3SLC16A1ALDH1A1MEN1 | |
| SCHEMBL6629870 | 0.64 | PDE5A (0.54) | PDE5ABRD4KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368352-B1 | CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS | PFIZER LTD (GB) | 2004-12-01 | — | — | EP | disclosed |