Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 7/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 6/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | CDC25A | P30304 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5347574 | 0.84 | CDK5 (0.65) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5342987 | 0.84 | CDK5 (0.57) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5342153 | 0.84 | CDK5 (0.57) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5341602 | 0.81 | CDK5 (0.54) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5342474 | 0.80 | CDK5 (0.53) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5345974 | 0.79 | CDK5 (0.54) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5339059 | 0.78 | CDK5 (0.51) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5339544 | 0.78 | CDK5 (0.51) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL14558890 | 0.78 | CDK5 (0.53) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5344451 | 0.75 | CDK5 (0.54) | CDK5CDK5R1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483263-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003070727-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-08-28 | — | — | WO | disclosed |
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |