Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.43 |
| ▸ | PDE1A | P54750 | 2/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.42 |
| ▸ | PDE6D | O43924 | 1/20 | 0.42 |
| ▸ | PDE8A | O60658 | 1/20 | 0.42 |
| ▸ | PDE9A | O76083 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | PDE6A | P16499 | 1/20 | 0.42 |
| ▸ | PDE6G | P18545 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629280 | 0.86 | PDE5A (0.52) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL6630131 | 0.79 | PDE5A (0.50) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL6630455 | 0.79 | KMT2A (0.45) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL6629094 | 0.79 | KMT2A (0.45) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL6811479 | 0.78 | PDE5A (0.53) | PDE5APDE6CPDE11A | |
| SCHEMBL6630690 | 0.78 | KMT2A (0.43) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL6629425 | 0.77 | PDE5A (0.62) | PDE5APDE3BPDE3APDE6CPDE11A | |
| SCHEMBL6631741 | 0.75 | PDE5A (0.49) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL6630863 | 0.75 | PDE5A (0.60) | PDE5APDE3BPDE3APDE6CPDE11A | |
| SCHEMBL6630217 | 0.74 | POLB (0.51) | PDE5APDE6CPDE11AKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368352-B1 | CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS | PFIZER LTD (GB) | 2004-12-01 | — | — | EP | claimed |