Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTBP2 | P56545 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6630640 | 1.00 | CTBP2 (0.52) | CTBP2CES1CES2AKR1B1ALDH1A1 | |
| SCHEMBL3966062 | 0.80 | CTBP2 (0.56) | CTBP2CES1CES2AKR1B1ALDH1A1 | |
| SCHEMBL11652991 | 0.77 | CTBP2 (0.48) | CTBP2CES1CES2AKR1B1ALDH1A1 | |
| SCHEMBL11652989 | 0.77 | CTBP2 (0.48) | CTBP2CES1CES2AKR1B1ALDH1A1 | |
| SCHEMBL3084457 | 0.75 | CTBP2 (0.75) | CTBP2CES1CES2AKR1B1HIF1A | |
| SCHEMBL3084459 | 0.75 | CTBP2 (0.75) | CTBP2CES1CES2AKR1B1HIF1A | |
| SCHEMBL3084456 | 0.75 | CTBP2 (0.75) | CTBP2CES1CES2AKR1B1HIF1A | |
| SCHEMBL2640208 | 0.74 | CTBP2 (0.50) | CTBP2CES1CES2AKR1B1ALDH1A1 | |
| SCHEMBL28863069 | 0.74 | CTBP2 (0.46) | CTBP2CES1CES2AKR1B1ALDH1A1 | |
| SCHEMBL575074 | 0.74 | AKR1B1 (0.62) | CTBP2CES1CES2AKR1B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385847-A2 | PYRAZOLO[1,5-A]PYRIDINE DERIVATIVES | SmithKline Beecham Corporation (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002088124-A2 | PYRAZOLO'1,5-A!PYRIDINE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-11-07 | — | — | WO | disclosed |