Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 8/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5891645 | 0.91 | ADORA2A (0.43) | AVPR2AVPR1ALMNANPC1RAB9A | |
| SCHEMBL5891125 | 0.91 | AVPR2 (0.53) | AVPR2AVPR1ALMNANPC1POLB | |
| SCHEMBL5891044 | 0.89 | AVPR2 (0.47) | AVPR2AVPR1ANPC1RAB9AKDM4E | |
| SCHEMBL5891117 | 0.88 | AVPR2 (0.38) | AVPR2AVPR1AKDM4ENAMPTROCK2 | |
| SCHEMBL3553530 | 0.86 | HTT (0.43) | AVPR2AVPR1ALMNAHTTKDM4E | |
| SCHEMBL5890750 | 0.86 | AVPR2 (0.47) | AVPR2AVPR1AKDM4ENAMPTROCK2 | |
| SCHEMBL5891130 | 0.85 | NAMPT (0.42) | AVPR2AVPR1ANPC1HTTNAMPT | |
| SCHEMBL5891188 | 0.85 | AVPR2 (0.51) | AVPR2AVPR1ANPC1RAB9AKDM4E | |
| SCHEMBL5891126 | 0.84 | AVPR2 (0.42) | AVPR2AVPR1ANPC1HTTNAMPT | |
| SCHEMBL5891601 | 0.84 | AVPR2 (0.49) | AVPR2AVPR1ALMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002083683-A9 | NOVEL TRICYCLIC PYRIDYL BENZAZEPINE CARBOXAMIDES AND DERIVATIVES THEREOF TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | WYETH CORP (US) | 2004-02-26 | — | — | WO | disclosed |
| EP-1377581-A1 | NOVEL TRICYCLIC PYRIDYL BENZAZEPINE CARBOXAMIDES AND DERIVATIVES THEREOF AS TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | Wyeth (US) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002083683-A1 | NOVEL TRICYCLIC PYRIDYL BENZAZEPINE CARBOXAMIDES AND DERIVATIVES THEREOF TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | WYETH (US) | 2002-10-24 | — | — | WO | disclosed |