Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3824396 | 0.85 | ESR1 (0.46) | ESR1ESR2PDK2PKMABHD6 | |
| SCHEMBL2585109 | 0.78 | ESR1 (0.62) | ESR1ESR2NOTUMHTR2AHTR2C | |
| SCHEMBL25206226 | 0.76 | ESR2 (0.76) | ESR1ESR2RIPK1PKMABHD6 | |
| SCHEMBL29989790 | 0.76 | ESR1 (0.76) | ESR1ESR2RIPK1AXLTYRO3 | |
| SCHEMBL2821470 | 0.76 | ESR1 (0.76) | ESR1ESR2RIPK1AXLTYRO3 | |
| SCHEMBL1095888 | 0.74 | ESR1 (0.58) | ESR1ESR2NOTUMPDK2RIPK1 | |
| SCHEMBL1095848 | 0.73 | ESR1 (0.56) | ESR1ESR2NOTUMPDK2RIPK1 | |
| SCHEMBL3282323 | 0.72 | ESR1 (0.49) | ESR1ESR2CNR1HTR2AHTR2C | |
| SCHEMBL3282297 | 0.72 | ESR1 (0.49) | ESR1ESR2CNR1HTR2AHTR2C | |
| SCHEMBL31121204 | 0.72 | ESR1 (0.49) | ESR1ESR2CNR1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411881-A4 | 5HT sb 2C /sb RECEPTOR MODULATORS | ARENA PHARM INC (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1411881-A2 | 5HT sb 2C /sb RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003086306-A2 | 5HT2C RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |