Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 8/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.35 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5342297 | 0.95 | CDK5 (0.47) | CDK5CDK5R1DYRK1ACCNA2CDK2 | |
| SCHEMBL5345512 | 0.91 | CDK5 (0.61) | CDK5CDK5R1DYRK1ACCNA2CDK2 | |
| SCHEMBL5344526 | 0.90 | CDK5 (0.49) | CDK5CDK5R1DYRK1AROCK1 | |
| SCHEMBL5342417 | 0.88 | CDK5 (0.51) | CDK5CDK5R1DYRK1ACCNA2CDK2 | |
| SCHEMBL5343463 | 0.88 | CDK5 (0.47) | CDK5CDK5R1DYRK1AROCK1 | |
| SCHEMBL5338010 | 0.87 | CDK5 (0.53) | CDK5CDK5R1DYRK1ACCNA2CDK2 | |
| SCHEMBL14558881 | 0.85 | ACKR3 (0.48) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL6630678 | 0.85 | CDK5 (0.53) | CDK5CDK5R1DYRK1ACCNA2CDK2 | |
| SCHEMBL6629746 | 0.85 | BTK (0.41) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5337550 | 0.82 | CDK5 (0.46) | CDK5CDK5R1DYRK1ACCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483263-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003070727-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-08-28 | — | — | WO | disclosed |
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |