Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 4/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632690 | 1.00 | PDE1A (0.42) | PDE1APDE1BPDE1CMEN1KMT2A | |
| SCHEMBL5404321 | 0.86 | PDE1A (0.36) | PDE1APDE1BPDE1CMEN1KMT2A | |
| SCHEMBL5411358 | 0.81 | PDE1A (0.40) | PDE1APDE1BPDE1CPDE2ALMNA | |
| SCHEMBL5411362 | 0.81 | PDE1A (0.40) | PDE1APDE1BPDE1CPDE2ALMNA | |
| SCHEMBL5407580 | 0.81 | PDE1A (0.41) | PDE1APDE1BPDE1CMEN1KMT2A | |
| SCHEMBL5407590 | 0.81 | PDE1A (0.41) | PDE1APDE1BPDE1CMEN1KMT2A | |
| SCHEMBL5397647 | 0.80 | PDE1A (0.36) | PDE1APDE1BPDE1CMEN1KMT2A | |
| SCHEMBL5397654 | 0.80 | PDE1A (0.36) | PDE1APDE1BPDE1CMEN1KMT2A | |
| SCHEMBL5407992 | 0.80 | TP53 (0.42) | PDE1APDE1BPDE1CLMNAALDH1A1 | |
| SCHEMBL5403918 | 0.80 | PDE1A (0.39) | PDE1APDE1BPDE1CMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412355-A1 | NEW PYRAZOLO(3,4-D)PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | AstraZeneca AB (SE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003002567-A1 | NEW PYRAZOLO[3,4-D]PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | WO | disclosed |