Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6634646 | 0.94 | CHRNA7 (0.64) | CHRNA7HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL4037783 | 0.88 | CHRNA7 (0.70) | CHRNA7HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL15624886 | 0.85 | CHRNA7 (0.94) | CHRNA7HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL1447408 | 0.85 | HRH3 (0.71) | CHRNA7HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL3915425 | 0.84 | CHRNA7 (0.68) | CHRNA7HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL10412133 | 0.84 | HPGD (0.69) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3916711 | 0.83 | HRH3 (0.67) | CHRNA7HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL3920077 | 0.83 | CHRNA7 (0.67) | CHRNA7HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL4039036 | 0.82 | CHRNA7 (0.66) | CHRNA7HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL3926220 | 0.82 | CHRNA7 (0.65) | CHRNA7HRH3ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436291-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | Aventis Pharma S.A. (FR) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003024967-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2003-03-27 | — | — | WO | disclosed |