Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.72 |
| ▸ | INSR | P06213 | 7/20 | 0.72 |
| ▸ | LYN | P07948 | 4/20 | 0.72 |
| ▸ | LCK | P06239 | 4/20 | 0.72 |
| ▸ | KIT | P10721 | 4/20 | 0.72 |
| ▸ | KDR | P35968 | 4/20 | 0.72 |
| ▸ | RET | P07949 | 4/20 | 0.72 |
| ▸ | SRC | P12931 | 3/20 | 0.72 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.72 |
| ▸ | FLT1 | P17948 | 3/20 | 0.72 |
| ▸ | FLT4 | P35916 | 3/20 | 0.72 |
| ▸ | FLT3 | P36888 | 3/20 | 0.72 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.72 |
| ▸ | BTK | Q06187 | 3/20 | 0.72 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.72 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.72 |
| ▸ | EGFR | P00533 | 2/20 | 0.72 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.72 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.72 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640150 | 0.98 | IGF1R (0.72) | IGF1RINSRLYNLCKKIT | |
| SCHEMBL31652487 | 0.98 | IGF1R (0.72) | IGF1RINSRLYNLCKKIT | |
| SCHEMBL6639376 | 0.97 | IGF1R (0.71) | IGF1RINSRLYNLCKKIT | |
| SCHEMBL6635961 | 0.97 | IGF1R (0.71) | IGF1RINSRLYNLCKKIT | |
| SCHEMBL6636487 | 0.85 | IGF1R (0.58) | IGF1RINSRLYNLCKKIT | |
| SCHEMBL6636964 | 0.85 | IGF1R (0.53) | IGF1RINSRLYNLCKKIT | |
| SCHEMBL94862 | 0.84 | IGF1R (1.00) | IGF1RINSRLYNLCKKIT | |
| SCHEMBL1987652 | 0.84 | IGF1R (1.00) | IGF1RINSRLYNLCKKIT | |
| SCHEMBL29561027 | 0.84 | IGF1R (1.00) | IGF1RINSRLYNLCKKIT | |
| SCHEMBL1441421 | 0.84 | IGF1R (1.00) | IGF1RINSRLYNLCKKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390369-A1 | 4-AMINO-5-PHENYL-7-CYCLOBUTYL-PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES | Novartis AG (CH) | 2004-02-25 | — | — | EP | claimed |
| WO-2002092599-A1 | 4-AMINO-5-PHENYL-7-CYCLOBUTYL-PYRROLO (2,3-D) PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2002-11-21 | — | — | WO | claimed |
| EP-1476192-A1 | METHODS AND COMPOSITIONS FOR TREATING HYPERPROLIFERATIVE CONDITIONS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068265-A1 | METHODS AND COMPOSITIONS FOR TREATING HYPERPROLIFERATIVE CONDITIONS | DANA-FARBER CANCER INSTITUTE INC. (US) | 2003-08-21 | — | — | WO | disclosed |