Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.76 |
| ▸ | ESR1 | P03372 | 1/20 | 0.76 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.76 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.76 |
| ▸ | PDE4A | P27815 | 1/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.76 |
| ▸ | GCGR | P47871 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | PDE6D | O43924 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27303140 | 0.94 | HMGCR (0.85) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL6856960 | 0.93 | HMGCR (0.89) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL23366186 | 0.93 | HMGCR (0.89) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL6633443 | 0.91 | HMGCR (0.75) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL8953500 | 0.88 | HMGCR (0.73) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9153939 | 0.88 | HMGCR (0.73) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL13847654 | 0.88 | HMGCR (0.72) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL10362835 | 0.88 | HMGCR (0.70) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL27303144 | 0.87 | HMGCR (0.73) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| Cerivastatin SCHEMBL5508956 | 0.86 | HMGCR (1.00) | HMGCRESR1CHRM1TBXA2RPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0818447-B1 | 6-(Hydroxymethyl-ethyl)pyridines as HMG-CoA-reductase inhibitors | BAYER HEALTHCARE AG (DE) | 2004-05-26 | — | — | EP | disclosed |
| EP-0818447-A1 | 6-(Hydroxymethyl-ethyl)pyridines as HMG-CoA-reductase inhibitors | BAYER AG (DE) | 1998-01-14 | — | — | EP | disclosed |