SCHEMBL6633463

SCHEMBL6633463

CCOC(=O)CN(c1ccc2oc(CCc3ccc(C#N)cc3)nc2c1)S(=O)(=O)c1cccc2cccnc12

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
F2 P00734 5/20 0.45
PKM P14618 1/20 0.39
TSHR P16473 2/20 0.38
GAA P10253 1/20 0.38
ALDH1A1 P00352 2/20 0.38
FNTA P49354 1/20 0.37
FNTB P49356 1/20 0.37
PGGT1B P53609 1/20 0.37
MAPT P10636 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
PTPN2 P17706 1/20 0.35
PTPN1 P18031 1/20 0.35
STAT3 P40763 1/20 0.35
PTPRS Q13332 1/20 0.35
HCRTR2 O43614 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6642022 0.88 F2 (0.59) F2PKMTSHRGAAALDH1A1
SCHEMBL6635157 0.87 F2 (0.44) F2PKMALDH1A1FNTAFNTB
SCHEMBL6637732 0.85 F2 (0.43) F2PKMTSHRGAAALDH1A1
SCHEMBL6635031 0.85 F2 (0.45) F2PKMTSHRGAAALDH1A1
SCHEMBL6639498 0.84 F2 (0.56) F2TSHRGAAALDH1A1FNTA
SCHEMBL6638786 0.84 F2 (0.65) F2TSHRGAAALDH1A1FNTA
SCHEMBL6635727 0.82 F2 (0.49) F2TSHRGAAALDH1A1FNTA
SCHEMBL8032187 0.82 F2 (0.42) F2PKMTSHRGAAALDH1A1
SCHEMBL6640095 0.82 F2 (0.55) F2TSHRGAAALDH1A1FNTA
SCHEMBL6638848 0.81 F2 (0.52) F2TSHRGAAALDH1A1FNTA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1100795-B1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM PHARMA (DE) 2004-06-09 EP disclosed
EP-1100795-A1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM ZENTRALE GMBH (DE) 2001-05-23 EP disclosed
US-6121308-A INDOLE AND BENZIMIDAZOLE ANTITHROMBOTIC COMPOUNDS, SUCH AS 1-METHYL-2-(N-(4-AMIDINOPHENYL)-AMINOMETHYL)-5-(N-(HYDROXYCARBONYLMETHYL) -QUINOLINE-8-SULPHONYLAMINO)-INDOLE BOEHRINGER INGELHEIM KG (DE) 2000-09-19 US disclosed
WO-2000008014-A1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-02-17 WO disclosed