SCHEMBL6633464

SCHEMBL6633464

Cc1onc2cc(C(=O)N[C@@H]3C4CCN(CC4)[C@H]3C)ccc12

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 16/20 0.41
TAS1R3 Q7RTX0 1/20 0.39
TAS1R1 Q7RTX1 1/20 0.39
TAS1R2 Q8TE23 1/20 0.39
CHRNB2 P17787 3/20 0.38
CHRNA4 P43681 3/20 0.38
CNR1 P21554 1/20 0.38
CNR2 P34972 1/20 0.38
HTR3A P46098 1/20 0.38
MAPK13 O15264 1/20 0.36
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6631573 0.92 CHRNA7 (0.41) CHRNA7TAS1R3TAS1R1TAS1R2CHRNB2
SCHEMBL6630636 0.83 MLLT1 (0.46) CHRNA7CHRNB2CHRNA4CNR1CNR2
SCHEMBL6631215 0.81 MAPK14 (0.53) CHRNA7CHRNB2CHRNA4CNR1CNR2
SCHEMBL6632414 0.81 CHRNA7 (0.40) CHRNA7CHRNB2CHRNA4CNR1CNR2
SCHEMBL6630574 0.80 CHRNA7 (0.58) CHRNA7HTR3A
SCHEMBL6634376 0.80 CHRNA7 (0.58) CHRNA7HTR3A
SCHEMBL6634176 0.79 CHRNA7 (0.63) CHRNA7TAS1R3TAS1R1CHRNB2CHRNA4
SCHEMBL6629398 0.77 NAMPT (0.46) CHRNA7CHRNB2CHRNA4HTR3A
SCHEMBL6756936 0.77 CHRNA7 (0.52) CHRNA7CHRNB2CHRNA4CNR1CNR2
SCHEMBL6654035 0.77 CHRNA7 (0.40) CHRNA7CHRNB2CHRNA4CNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1404674-A2 QUINUCLIDINE-SUBSTITUTED HETEROAROMATIC COMPOUNDS AS LIGANDS AT NICOTINIC ACETYLCHOLINE RECEPTORS PHARMACIA & UPJOHN COMPANY (US) 2004-04-07 EP claimed
WO-2002100858-A2 QUINUCLIDINE-SUBSTITUTED HETEROAROMATIC COMPOUNDS AS LIGANDS AT NICOTINIC ACETYLCHOLINE RECEPTORS PHARMACIA & UPJOHN COMPANY (US) 2002-12-19 WO claimed