SCHEMBL6633898

SCHEMBL6633898

OCC#CCc1cc2c(S)c(C(=S)NCc3ccc(Cl)cc3)cnc2s1

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6347826 0.88 RXFP1 (0.36) RXFP1
SCHEMBL6337982 0.86 SMN1; SMN2 (0.33) SMN1; SMN2
SCHEMBL6340795 0.85 RXFP1 (0.34) RXFP1
SCHEMBL6340791 0.81 SMN1; SMN2 (0.35) SMN1; SMN2
SCHEMBL6339994 0.81 MAPT (0.37) SMN1; SMN2
SCHEMBL6339252 0.81 SMN1; SMN2 (0.34) RXFP1SMN1; SMN2
SCHEMBL6336604 0.80 SMN1; SMN2 (0.32) SMN1; SMN2
SCHEMBL7646442 0.80 SMN1; SMN2 (0.43) RXFP1SMN1; SMN2
SCHEMBL6339478 0.79 KCNH2 (0.51) RXFP1
SCHEMBL6339561 0.77 SMN1; SMN2 (0.36) SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003020728-A1 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2003-03-13 WO claimed
EP-1421088-A1 4-THIOXO-4,7-DIHYDRO-THIENO 2,3-B]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2004-05-26 EP disclosed
WO-2003020730-A1 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-B]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2003-03-13 WO disclosed