Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 19/20 | 0.68 |
| ▸ | PPARA | Q07869 | 13/20 | 0.68 |
| ▸ | PPARG | P37231 | 11/20 | 0.68 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619400 | 0.97 | PPARD (0.64) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL6860510 | 0.92 | PPARD (0.58) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL6625015 | 0.90 | PPARD (0.65) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL6632768 | 0.89 | PPARD (0.54) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL6621552 | 0.88 | PPARD (0.66) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL5511576 | 0.83 | PPARD (0.75) | PPARDPPARAPPARG | |
| SCHEMBL6624010 | 0.82 | PPARD (0.55) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL4673921 | 0.82 | PPARD (0.81) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL5507328 | 0.81 | PPARD (1.00) | PPARDPPARAPPARG | |
| SCHEMBL6617715 | 0.81 | PPARD (0.56) | PPARDPPARAPPARGFFAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833380-B2 | Thiazole or oxazole derivatives such as (4-(4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl)-5-oxo -5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid | WARNER-LAMBERT COMPANY, LLC | 2004-12-21 | — | — | US | claimed |
| EP-1485091-A1 | THIAZOLE AND OXAZOLE DERIVATIVES THAT MODULATE PPAR ACTIVITY | Warner-Lambert Company LLC (US) | 2004-12-15 | — | — | EP | claimed |
| US-20030207916-A1 | Thiazole or oxazole derivatives such as (4-(4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl)-5-oxo -5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid | CHENG XUE-MIN (US) | 2003-11-06 | — | — | US | claimed |
| WO-2003074052-A1 | THIAZOLE AND OXAZOLE DERIVATIVES THAT MODULATE PPAR ACTIVITY | WARNER-LAMBERT COMPANY LLC (US) | 2003-09-12 | — | — | WO | claimed |
| US-6833380-B2 | Thiazole or oxazole derivatives such as (4-(4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl)-5-oxo -5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid | WARNER-LAMBERT COMPANY, LLC | 2004-12-21 | — | — | US | disclosed |
| EP-1485091-A1 | THIAZOLE AND OXAZOLE DERIVATIVES THAT MODULATE PPAR ACTIVITY | Warner-Lambert Company LLC (US) | 2004-12-15 | — | — | EP | disclosed |
| US-20030207916-A1 | Thiazole or oxazole derivatives such as (4-(4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl)-5-oxo -5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid | CHENG XUE-MIN (US) | 2003-11-06 | — | — | US | disclosed |
| WO-2003074052-A1 | THIAZOLE AND OXAZOLE DERIVATIVES THAT MODULATE PPAR ACTIVITY | WARNER-LAMBERT COMPANY LLC (US) | 2003-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207916-A1 | Thiazole or oxazole derivatives such as (4-(4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl)-5-oxo -5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid | PPARA, PPARD, PPARG | PPARD 2/4885PPARA 1/4885PPARG 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.