Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 19/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5337241 | 0.87 | CCNA2 (0.47) | IKBKBCCNA2CDK2CCNA1CHUK | |
| SCHEMBL6618376 | 0.86 | IKBKB (0.42) | IKBKBCCNA2CDK2CCNA1 | |
| SCHEMBL5346459 | 0.85 | IKBKB (0.49) | IKBKBCCNA2CDK2CCNA1CHUK | |
| SCHEMBL5405030 | 0.81 | IKBKB (0.50) | IKBKBCCNA2CDK2CCNA1CHUK | |
| SCHEMBL5343708 | 0.81 | IKBKB (0.57) | IKBKBCCNA2CDK2CCNA1CHUK | |
| SCHEMBL5339927 | 0.80 | CCNA2 (0.61) | IKBKBCCNA2CDK2CCNA1CHUK | |
| SCHEMBL5337449 | 0.80 | IKBKB (0.63) | IKBKBCHUK | |
| SCHEMBL5348037 | 0.80 | IKBKB (0.54) | IKBKBCCNA2CDK2CCNA1CHUK | |
| SCHEMBL5340843 | 0.79 | CCNA2 (0.49) | IKBKBCCNA2CDK2CCNA1CHUK | |
| SCHEMBL5338256 | 0.78 | IKBKB (0.51) | IKBKBCCNA2CDK2CCNA1CHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444207-A2 | SUBSTITUTED PYRAZOLYL-COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2004-08-11 | — | — | EP | claimed |
| WO-2003024935-A2 | SUBSTITUTED PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-03-27 | — | — | WO | claimed |