Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 7/20 | 0.54 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6099455 | 1.00 | CHRNA7 (0.54) | CHRNA7USP30AURKAAURKBMAP3K5 | |
| SCHEMBL6099459 | 1.00 | CHRNA7 (0.54) | CHRNA7USP30AURKAAURKBMAP3K5 | |
| SCHEMBL6100836 | 0.94 | CHRNA7 (0.46) | CHRNA7USP30AURKAAURKBMAP3K5 | |
| SCHEMBL6634837 | 0.87 | CHRNA7 (0.55) | CHRNA7USP30 | |
| SCHEMBL6097044 | 0.87 | CHRNA7 (0.55) | CHRNA7USP30 | |
| SCHEMBL6097036 | 0.87 | CHRNA7 (0.55) | CHRNA7USP30 | |
| SCHEMBL6099218 | 0.86 | CHRNA7 (0.54) | CHRNA7USP30HPGDCHRM4 | |
| SCHEMBL6099210 | 0.86 | CHRNA7 (0.54) | CHRNA7USP30HPGDCHRM4 | |
| SCHEMBL6098178 | 0.86 | CHRNA7 (0.51) | CHRNA7 | |
| SCHEMBL6098174 | 0.86 | CHRNA7 (0.51) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478646-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003072578-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |