Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 18/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.54 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1916872 | 0.87 | FLT3 (0.60) | PTK2CHEK1FLT3JAK2NTRK1 | |
| SCHEMBL3283893 | 0.87 | CHEK1 (0.63) | PTK2CHEK1FLT3JAK2NTRK1 | |
| SCHEMBL1917544 | 0.86 | PTK2 (0.71) | PTK2CHEK1FLT3JAK2NTRK1 | |
| SCHEMBL1916885 | 0.86 | CHEK1 (0.68) | PTK2CHEK1FLT3JAK2NTRK1 | |
| SCHEMBL6639386 | 0.85 | CYP3A4 (0.52) | PTK2CHEK1FLT3GSK3AGSK3B | |
| SCHEMBL1917639 | 0.84 | PTK2 (0.66) | PTK2CHEK1FLT3JAK2NTRK1 | |
| SCHEMBL1916946 | 0.84 | CHEK1 (0.57) | PTK2CHEK1FLT3JAK2NTRK1 | |
| SCHEMBL1919207 | 0.84 | CHEK1 (0.57) | PTK2CHEK1FLT3JAK2NTRK1 | |
| SCHEMBL3284837 | 0.84 | PTK2 (0.62) | PTK2CHEK1FLT3JAK2NTRK1 | |
| SCHEMBL3291976 | 0.83 | PTK2 (0.61) | PTK2CHEK1FLT3JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1438053-A1 | PYRIMIDINE DERIVATIVES, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS, USE AND METHOD FOR MAKING SAME | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003032997-A1 | PYRIMIDINE DERIVATIVES, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS, USE AND METHOD FOR MAKING SAME | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-04-24 | — | — | WO | disclosed |