Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.77 |
| ▸ | BTK | Q06187 | 8/20 | 0.77 |
| ▸ | LYN | P07948 | 12/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.57 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.57 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6642174 | 0.91 | SRC (0.72) | SRCBTKLYNFGFR1RIPK2 | |
| SCHEMBL6640968 | 0.87 | SRC (1.00) | SRCBTKLYNFGFR1RIPK2 | |
| SCHEMBL6640140 | 0.85 | SRC (0.80) | SRCBTKLYNFGFR1RIPK2 | |
| SCHEMBL6640079 | 0.84 | SRC (0.83) | SRCBTKLYNFGFR1RIPK2 | |
| SCHEMBL6640884 | 0.83 | SRC (0.82) | SRCBTKLYNFGFR1RIPK2 | |
| SCHEMBL6639181 | 0.83 | SRC (0.77) | SRCBTKLYNFGFR1RIPK2 | |
| SCHEMBL6638678 | 0.81 | SRC (0.73) | SRCBTKLYNFGFR1RIPK2 | |
| SCHEMBL6638542 | 0.81 | SRC (0.72) | SRCBTKLYNFGFR1RIPK2 | |
| SCHEMBL6641442 | 0.80 | SRC (0.71) | SRCBTKLYNFGFR1RIPK2 | |
| SCHEMBL6640961 | 0.80 | SRC (0.71) | SRCBTKLYNFGFR1RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003745-B1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2004-12-29 | — | — | EP | claimed |
| US-6150359-A | 1,6-NAPHTHYRIDIONE COMPOUNDS USEFUL FOR TREATING CANCER, RESTENOSIS AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 2000-11-21 | — | — | US | claimed |
| EP-1003745-B1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2004-12-29 | — | — | EP | disclosed |
| US-6150359-A | 1,6-NAPHTHYRIDIONE COMPOUNDS USEFUL FOR TREATING CANCER, RESTENOSIS AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 2000-11-21 | — | — | US | disclosed |