Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.37 |
| ▸ | NAMPT | P43490 | 4/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658073 | 0.81 | TRPV1 (0.41) | TRPV1HDAC6 | |
| SCHEMBL5659882 | 0.80 | TRPV1 (0.41) | TRPV1GPBAR1 | |
| SCHEMBL6622382 | 0.80 | TRPV1 (0.47) | TRPV1NR1H4KCNH2HDAC6 | |
| SCHEMBL5411314 | 0.78 | TRPV1 (0.53) | TRPV1 | |
| SCHEMBL6637455 | 0.75 | TRPV1 (0.45) | TRPV1HDAC6 | |
| SCHEMBL27642770 | 0.73 | TRPV1 (0.46) | TRPV1GPBAR1 | |
| SCHEMBL27663669 | 0.73 | TRPV1 (0.44) | TRPV1GPBAR1TRPM8 | |
| SCHEMBL6623343 | 0.73 | CYP3A4 (0.40) | TRPV1GPBAR1TRPM8 | |
| SCHEMBL5399647 | 0.73 | TRPV1 (0.57) | TRPV1GPBAR1KCNH2 | |
| SCHEMBL27642822 | 0.73 | TRPV1 (0.42) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490340-A1 | HETEROAROMATIC UREA DERIVATIVES AS VR-1 RECEPTOR MODULATORS FOR TREATING PAIN | MERCK SHARP & DOHME LTD. (GB) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003080578-A1 | HETEROAROMATIC UREA DERIVATIVES AS VR-1 RECEPTOR MODULATORS FOR TREATING PAIN | MERCK SHARP & DOHME LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |