Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224337 | 0.89 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL7858770 | 0.86 | EDNRA (0.76) | EDNRAEDNRB | |
| SCHEMBL6770783 | 0.83 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL6767337 | 0.83 | EDNRA (0.76) | EDNRAEDNRB | |
| SCHEMBL8674786 | 0.82 | EDNRA (0.72) | EDNRAEDNRB | |
| SCHEMBL6767574 | 0.81 | EDNRA (0.77) | EDNRAEDNRB | |
| SCHEMBL6770661 | 0.81 | EDNRA (0.71) | EDNRAEDNRB | |
| SCHEMBL2557314 | 0.81 | EDNRA (0.71) | EDNRAEDNRB | |
| SCHEMBL6151288 | 0.81 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL7849770 | 0.81 | EDNRA (1.00) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1066441-C | Phenyl sulfonamide endothelin antagonists | SQUIBB & SONS INC (US) | 2001-05-30 | — | — | CN | claimed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | claimed |
| CN-1084515-A | Phenyl sulfamoyl endothelium (endothelin) antagonistic | SQUIBB & SONS INC (US) | 1994-03-30 | — | — | CN | claimed |
| EP-0569193-A1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-11-10 | — | — | EP | claimed |
| CN-101838263-A | Benzimidazole derivative with cardiovascular activity and preparing method and application thereof | UNIV CHINA PHARMA | 2010-09-22 | — | — | CN | disclosed |
| EP-0921800-B1 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL MYERS SQUIBB CO (US) | 2004-04-14 | — | — | EP | disclosed |
| US-6673824-B1 | HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB CO. | 2004-01-06 | — | — | US | disclosed |
| EP-0702012-B1 | Substituted isoxazole sulfonamides and their use as endothelin antagonists | BRISTOL MYERS SQUIBB CO (US) | 2003-10-15 | — | — | EP | disclosed |
| US-6515136-B1 | To the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension. | BRISTOL-MYERS SQUIBB COMPANY | 2003-02-04 | — | — | US | disclosed |
| US-6271248-B1 | USED IN TREATING HYPERTENSION, PULMONARY HYPERTENSION, RENAL/ GLOMERULAR/MESANGIAL CELL DISORDERS, ENDOTOXEMIA, ISCHEMIA, TUMOR GROWTH, ATHERSCLEROSIS, RESTENOSIS, SUBARACHNOID HEMORRHAGE, PROSTATIC HYPERTROPHY, CONGESTIVE HEART FAILURE | BRISTOL-MYERS SQUIBB COMPANY | 2001-08-07 | — | — | US | disclosed |
| CN-1066441-C | Phenyl sulfonamide endothelin antagonists | SQUIBB & SONS INC (US) | 2001-05-30 | — | — | CN | disclosed |
| EP-0921800-A4 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL MYERS SQUIBB CO (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1997029748-A1 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-21 | — | — | WO | disclosed |
| EP-0768305-A1 | N-Isoxazolyl-biphenylsulfonamide derivatives, their preparation and their use as endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5612359-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5514696-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0702012-A1 | Substituted isoxazole sulfonamides and their use as endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-03-20 | — | — | EP | disclosed |
| CN-1084515-A | Phenyl sulfamoyl endothelium (endothelin) antagonistic | SQUIBB & SONS INC (US) | 1994-03-30 | — | — | CN | disclosed |
| EP-0569193-A1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-11-10 | — | — | EP | disclosed |