SCHEMBL6640883

SCHEMBL6640883

CC(Nc1nc(Nc2ccc(Cl)cc2)ncc1[N+](=O)[O-])C1CCNCC1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STK17A Q9UEE5 1/20 0.52
CYP3A4 P08684 2/20 0.47
CYP2C9 P11712 2/20 0.47
MEN1 O00255 1/20 0.47
CYP1A2 P05177 1/20 0.47
MAPT P10636 1/20 0.47
CYP2C19 P33261 1/20 0.47
KMT2A Q03164 1/20 0.47
MCL1 Q07820 1/20 0.47
PTK2B Q14289 1/20 0.47
GSK3B P49841 6/20 0.47
PRKCQ Q04759 4/20 0.44
GSK3A P49840 5/20 0.43
AURKA O14965 2/20 0.43
ALK Q9UM73 1/20 0.41
FLT3 P36888 1/20 0.41
EGFR P00533 1/20 0.40
SOS1 Q07889 1/20 0.40
IGF1R P08069 1/20 0.40
GRM5 P41594 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1917601 0.83 STK17A (0.47) STK17ACYP3A4CYP2C9MEN1CYP1A2
SCHEMBL5408199 0.82 STK17A (0.62) STK17ACYP3A4CYP2C9MEN1CYP1A2
SCHEMBL3291111 0.81 STK17A (0.43) STK17ACYP3A4CYP2C9MEN1CYP1A2
SCHEMBL1917449 0.78 STK17A (0.53) STK17ACYP3A4CYP2C9MEN1CYP1A2
SCHEMBL1916666 0.78 STK17A (0.60) STK17ACYP3A4CYP2C9MEN1CYP1A2
SCHEMBL3285346 0.78 MAPT (0.57) STK17ACYP3A4CYP2C9MEN1CYP1A2
SCHEMBL1917188 0.78 MAPT (0.57) STK17ACYP3A4CYP2C9MEN1CYP1A2
SCHEMBL5408153 0.77 STK17A (0.61) STK17ACYP3A4CYP2C9MEN1CYP1A2
SCHEMBL5408180 0.77 STK17A (0.66) STK17ACYP3A4CYP2C9MEN1CYP1A2
SCHEMBL6638054 0.77 STK17A (0.46) STK17ACYP3A4CYP2C9MEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1438053-A1 PYRIMIDINE DERIVATIVES, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS, USE AND METHOD FOR MAKING SAME Boehringer Ingelheim Pharma GmbH & Co.KG (DE) 2004-07-21 EP disclosed
WO-2003032997-A1 PYRIMIDINE DERIVATIVES, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS, USE AND METHOD FOR MAKING SAME BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2003-04-24 WO disclosed