Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 11/20 | 0.51 |
| ▸ | CCND1 | P24385 | 11/20 | 0.51 |
| ▸ | CDK2 | P24941 | 7/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.51 |
| ▸ | CCND2 | P30279 | 5/20 | 0.49 |
| ▸ | CCND3 | P30281 | 5/20 | 0.49 |
| ▸ | BTK | Q06187 | 5/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 4/20 | 0.42 |
| ▸ | LYN | P07948 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | PRKDC | P78527 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6641642 | 0.99 | CDK4 (0.51) | CDK4CCND1CDK2CCNA2CCND2 | |
| SCHEMBL6642593 | 0.99 | CDK4 (0.51) | CDK4CCND1CDK2CCNA2CCND2 | |
| SCHEMBL6640656 | 0.88 | FGFR1 (0.47) | CDK4CCND1CDK2CCNA2JAK2 | |
| SCHEMBL6640502 | 0.88 | CDK4 (0.59) | CDK4CCND1CDK2CCNA2CCND2 | |
| SCHEMBL6644113 | 0.87 | CDK4 (0.51) | CDK4CCND1CDK2CCNA2CCND2 | |
| SCHEMBL6641534 | 0.87 | CDK4 (0.58) | CDK4CCND1CDK2CCNA2CCND2 | |
| SCHEMBL6642297 | 0.87 | CDK4 (0.58) | CDK4CCND1CDK2CCNA2CCND2 | |
| SCHEMBL6642018 | 0.87 | CDK4 (0.58) | CDK4CCND1CDK2CCNA2CCND2 | |
| SCHEMBL6642012 | 0.87 | CDK4 (0.58) | CDK4CCND1CDK2CCNA2CCND2 | |
| SCHEMBL6639601 | 0.87 | CDK4 (0.58) | CDK4CCND1CDK2CCNA2CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003745-B1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2004-12-29 | — | — | EP | claimed |
| US-6150359-A | 1,6-NAPHTHYRIDIONE COMPOUNDS USEFUL FOR TREATING CANCER, RESTENOSIS AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 2000-11-21 | — | — | US | claimed |
| EP-1003745-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY LLC (US) | 2000-05-31 | — | — | EP | claimed |
| WO-1999009030-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-02-25 | — | — | WO | claimed |
| EP-1003745-B1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2004-12-29 | — | — | EP | disclosed |
| US-6150359-A | 1,6-NAPHTHYRIDIONE COMPOUNDS USEFUL FOR TREATING CANCER, RESTENOSIS AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 2000-11-21 | — | — | US | disclosed |