Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.56 |
| ▸ | CCND1 | P24385 | 4/20 | 0.56 |
| ▸ | CCND2 | P30279 | 4/20 | 0.56 |
| ▸ | CCND3 | P30281 | 4/20 | 0.56 |
| ▸ | FYN | P06241 | 4/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | WEE1 | P30291 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6639710 | 0.94 | CDK4 (0.48) | CDK4CCND1CCND2CCND3FYN | |
| SCHEMBL6640659 | 0.93 | CDK4 (0.47) | CDK4CCND1CCND2CCND3FYN | |
| SCHEMBL6640452 | 0.90 | MAPK8 (0.46) | CDK4CCND1CCND2CCND3FYN | |
| SCHEMBL6642404 | 0.89 | BTK (0.61) | CDK4CCND1CCND2CCND3FYN | |
| SCHEMBL6639193 | 0.86 | BTK (0.51) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL6642623 | 0.86 | CDK4 (0.69) | CDK4CCND1CCND2CCND3FYN | |
| SCHEMBL6640998 | 0.85 | CDK4 (0.49) | CDK4CCND1CCND2CCND3FYN | |
| SCHEMBL6641735 | 0.85 | FGFR1 (0.57) | CDK4CCND1CCND2CCND3FYN | |
| SCHEMBL6642141 | 0.85 | FGFR1 (0.68) | FYNFGFR1SRCBTKWEE1 | |
| SCHEMBL6640724 | 0.84 | SYK (0.42) | CDK4CCND1CCND2CCND3FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003745-B1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2004-12-29 | — | — | EP | claimed |
| US-6150359-A | 1,6-NAPHTHYRIDIONE COMPOUNDS USEFUL FOR TREATING CANCER, RESTENOSIS AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 2000-11-21 | — | — | US | claimed |
| EP-1003745-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY LLC (US) | 2000-05-31 | — | — | EP | claimed |
| WO-1999009030-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-02-25 | — | — | WO | claimed |
| EP-1003745-B1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2004-12-29 | — | — | EP | disclosed |
| US-6150359-A | 1,6-NAPHTHYRIDIONE COMPOUNDS USEFUL FOR TREATING CANCER, RESTENOSIS AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 2000-11-21 | — | — | US | disclosed |
| EP-1003745-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY LLC (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009030-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-02-25 | — | — | WO | disclosed |