Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 15/20 | 0.67 |
| ▸ | CCND1 | P24385 | 15/20 | 0.67 |
| ▸ | CCND2 | P30279 | 13/20 | 0.67 |
| ▸ | CCND3 | P30281 | 13/20 | 0.67 |
| ▸ | CDK2 | P24941 | 9/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.67 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.67 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.67 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.67 |
| ▸ | CDK1 | P06493 | 3/20 | 0.67 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.67 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.57 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.57 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.56 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640630 | 1.00 | CDK4 (0.67) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6638713 | 1.00 | CDK4 (0.67) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6641509 | 1.00 | CDK4 (0.67) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6642357 | 1.00 | CDK4 (0.67) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6642681 | 0.99 | CDK4 (0.65) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6640208 | 0.92 | CDK4 (0.57) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6640674 | 0.92 | CDK4 (0.57) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6640834 | 0.92 | CDK4 (0.69) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6642115 | 0.92 | CDK4 (0.69) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6641973 | 0.91 | CDK4 (0.68) | CDK4CCND1CCND2CCND3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003745-B1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2004-12-29 | — | — | EP | claimed |
| US-6150359-A | 1,6-NAPHTHYRIDIONE COMPOUNDS USEFUL FOR TREATING CANCER, RESTENOSIS AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 2000-11-21 | — | — | US | claimed |
| EP-1003745-B1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2004-12-29 | — | — | EP | disclosed |
| US-6150359-A | 1,6-NAPHTHYRIDIONE COMPOUNDS USEFUL FOR TREATING CANCER, RESTENOSIS AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 2000-11-21 | — | — | US | disclosed |