Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | INSR | P06213 | 2/20 | 0.53 |
| ▸ | MET | P08581 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | TEK | Q02763 | 2/20 | 0.53 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17113389 | 0.77 | SYK (0.52) | EGFRSYKFLT3PRKCDBRAF | |
| SCHEMBL4476385 | 0.77 | SYK (0.52) | EGFRSYKFLT3PRKCDBRAF | |
| SCHEMBL6642791 | 0.76 | IGF1R (0.71) | IGF1REGFRCDK2INSRMET | |
| SCHEMBL6319730 | 0.76 | IGF1R (0.71) | IGF1REGFRCDK2INSRMET | |
| SCHEMBL1172781 | 0.75 | PKMYT1 (0.64) | IGF1REGFRCDK2INSRMET | |
| SCHEMBL6312556 | 0.74 | IGF1R (0.69) | IGF1REGFRCDK2INSRMET | |
| SCHEMBL6320480 | 0.74 | IGF1R (0.69) | IGF1REGFRCDK2INSRMET | |
| SCHEMBL6318996 | 0.73 | IGF1R (0.67) | IGF1REGFRCDK2INSRMET | |
| SCHEMBL1172597 | 0.73 | SYK (0.43) | EGFRCDK2SYKFLT3AURKA | |
| SCHEMBL31592443 | 0.73 | IGF1R (0.65) | IGF1REGFRCDK2INSRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427421-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | Amgen Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |