Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.75 |
| ▸ | CDK4 | P11802 | 7/20 | 0.75 |
| ▸ | IGF1R | P08069 | 5/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29644990 | 0.86 | CDK4 (1.00) | CDK2CDK4IGF1RGSK3B | |
| SCHEMBL29644986 | 0.86 | CDK4 (1.00) | CDK2CDK4IGF1RGSK3B | |
| SCHEMBL5581900 | 0.86 | CDK4 (1.00) | CDK2CDK4IGF1RGSK3B | |
| SCHEMBL6641459 | 0.84 | CDK2 (0.79) | CDK2CDK4IGF1RGSK3BCHEK1 | |
| SCHEMBL6643974 | 0.81 | CDK4 (0.68) | CDK2CDK4IGF1RGSK3BCHEK1 | |
| SCHEMBL6644486 | 0.78 | CDK4 (0.86) | CDK2CDK4IGF1RCHEK1NTRK2 | |
| SCHEMBL6826387 | 0.78 | CDK2 (0.64) | CDK2CDK4IGF1RGSK3BCHEK1 | |
| SCHEMBL6829108 | 0.78 | CDK2 (0.64) | CDK2CDK4IGF1RGSK3BCHEK1 | |
| SCHEMBL6829794 | 0.78 | CDK2 (0.64) | CDK2CDK4IGF1RGSK3BCHEK1 | |
| SCHEMBL6644644 | 0.78 | CDK4 (0.75) | CDK2CDK4IGF1RNTRK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140860-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-09-22 | — | — | EP | disclosed |
| US-6593326-B1 | Useful as anti-cancer agents; and processes for their manufacture and pharmaceutical compositions containing them are described. Apoptotic effect in a warm-blooded animal such as man. | ASTRAZENECA AB (SE) | 2003-07-15 | — | — | US | disclosed |