Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | ERN1 | O75460 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 5/20 | 0.47 |
| ▸ | CA2 | P00918 | 5/20 | 0.47 |
| ▸ | CA12 | O43570 | 4/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.47 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9950445 | 0.86 | CDK8 (0.59) | EGFRNOTUMERN1CA1CA2 | |
| SCHEMBL205408 | 0.81 | CA1 (0.48) | KDM4EALDH1A1CA1CA2CA12 | |
| SCHEMBL6638344 | 0.80 | NOTUM (0.63) | EGFRKDM4EALDH1A1NOTUMERN1 | |
| SCHEMBL19387238 | 0.78 | CA1 (0.70) | EGFRKDM4EALDH1A1ERN1CA1 | |
| Biphenyl Dimethyl Dicarboxylate SCHEMBL68521 | 0.78 | CA1 (0.70) | EGFRKDM4EALDH1A1ERN1CA1 | |
| SCHEMBL7853544 | 0.78 | CA1 (0.50) | KDM4EALDH1A1CA1CA2CA12 | |
| SCHEMBL16749655 | 0.77 | CA1 (0.58) | EGFRKDM4EALDH1A1ERN1CA1 | |
| SCHEMBL10009170 | 0.77 | CA1 (0.61) | EGFRKDM4EALDH1A1ERN1CA1 | |
| SCHEMBL16749645 | 0.77 | CA1 (0.61) | EGFRKDM4EALDH1A1ERN1CA1 | |
| Biphenyl Dimethyl Dicarboxylate SCHEMBL2890577 | 0.76 | CA1 (0.67) | EGFRKDM4EALDH1A1ERN1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931060-A4 | SUBSTITUTED N- (AMINOIMINOMETHYL OR AMINOMETHYL)PHENYL]PROPYL AMIDES | AVENTIS PHARMA INC (US) | 2004-10-06 | — | — | EP | disclosed |
| EP-0931060-A1 | SUBSTITUTED N- (AMINOIMINOMETHYL OR AMINOMETHYL)PHENYL]PROPYL AMIDES | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-07-28 | — | — | EP | disclosed |
| WO-1999000356-A1 | SUBSTITUTED N-[(AMINOIMINOMETHYL OR AMINOMETHYL)PHENYL]PROPYL AMIDES | RHÔNE-POULENC RORER PHARMACEUTICALS INC. (US) | 1999-01-07 | — | — | WO | disclosed |