Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766886 | 1.00 | NPSR1 (0.45) | NPSR1MITFMAPTHTTCYP19A1 | |
| SCHEMBL5766887 | 1.00 | NPSR1 (0.45) | NPSR1MITFMAPTHTTCYP19A1 | |
| SCHEMBL5765997 | 0.89 | NPSR1 (0.46) | NPSR1MITFMAPTHTTCYP19A1 | |
| SCHEMBL5765999 | 0.89 | NPSR1 (0.46) | NPSR1MITFMAPTHTTCYP19A1 | |
| SCHEMBL6649131 | 0.89 | NPSR1 (0.46) | NPSR1MITFMAPTHTTCYP19A1 | |
| SCHEMBL6242348 | 0.89 | SMN1; SMN2 (0.45) | NPSR1PTPN1PREPNPC1RAB9A | |
| SCHEMBL6242346 | 0.89 | SMN1; SMN2 (0.45) | NPSR1PTPN1PREPNPC1RAB9A | |
| SCHEMBL6645970 | 0.87 | NPSR1 (0.45) | NPSR1MITFMAPTHTTCYP19A1 | |
| SCHEMBL5765207 | 0.87 | NPSR1 (0.45) | NPSR1MITFMAPTHTTCYP19A1 | |
| SCHEMBL5765206 | 0.87 | NPSR1 (0.45) | NPSR1MITFMAPTHTTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377577-A1 | PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES | Sankyo Company Limited (JP) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002057264-A1 | PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES | SANKYO COMPANY LIMITED (JP) | 2002-07-25 | — | — | WO | disclosed |