Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764867 | 1.00 | POLB (0.42) | POLBHTR2CPSEN1PSEN2APH1B | |
| SCHEMBL6643705 | 0.86 | POLB (0.44) | POLBHTR2CPSEN1PSEN2APH1B | |
| SCHEMBL5763694 | 0.86 | POLB (0.44) | POLBHTR2CPSEN1PSEN2APH1B | |
| SCHEMBL6645775 | 0.85 | HTR2C (0.46) | POLBHTR2CPSEN1PSEN2APH1B | |
| SCHEMBL5251226 | 0.85 | HTR2C (0.46) | POLBHTR2CPSEN1PSEN2APH1B | |
| SCHEMBL9639899 | 0.84 | POLB (0.52) | POLBHTR2CPSEN1PSEN2APH1B | |
| SCHEMBL6643027 | 0.83 | POLB (0.42) | POLBHTR2CPSEN1PSEN2APH1B | |
| SCHEMBL5763632 | 0.83 | POLB (0.42) | POLBHTR2CPSEN1PSEN2APH1B | |
| SCHEMBL5764949 | 0.83 | PSEN1 (0.42) | POLBHTR2CPSEN1PSEN2APH1B | |
| SCHEMBL6644856 | 0.83 | PSEN1 (0.42) | POLBHTR2CPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377577-A1 | PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES | Sankyo Company Limited (JP) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002057264-A1 | PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES | SANKYO COMPANY LIMITED (JP) | 2002-07-25 | — | — | WO | disclosed |