Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5258740 | 0.83 | DDR1 (0.38) | DDR1MAOBEPHX2ADORA2AADORA1 | |
| SCHEMBL2203635 | 0.82 | DDR1 (0.42) | DDR1MAOBEPHX2ADORA2AADORA1 | |
| SCHEMBL13998917 | 0.79 | DDR1 (0.36) | DDR1MAOBEPHX2ADORA2AADORA1 | |
| SCHEMBL5128894 | 0.78 | DDR1 (0.41) | DDR1MAOBEPHX2ADORA2AADORA1 | |
| SCHEMBL5252169 | 0.77 | DDR1 (0.40) | DDR1MAOBEPHX2NTRK1KCNE1 | |
| SCHEMBL5120525 | 0.76 | DDR1 (0.35) | DDR1MAOBEPHX2NTRK1TYK2 | |
| Trifluoroacetic Acid SCHEMBL5127989 | 0.76 | DDR1 (0.38) | DDR1MAOBEPHX2ADORA2AADORA1 | |
| SCHEMBL5304414 | 0.73 | DDR1 (0.38) | DDR1MAOBEPHX2PPARGTRPV1 | |
| SCHEMBL5114973 | 0.72 | DDR1 (0.35) | DDR1MAOBEPHX2NTRK1 | |
| SCHEMBL13998916 | 0.72 | DDR1 (0.34) | DDR1MAOBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441734-A1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003035076-A1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-05-01 | — | — | WO | disclosed |