Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 18/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.53 |
| ▸ | SRC | P12931 | 7/20 | 0.47 |
| ▸ | SYK | P43405 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6298745 | 0.93 | GSK3A (0.60) | GSK3AMAPK14SRCSYKKDM4E | |
| SCHEMBL6300955 | 0.89 | GSK3A (0.52) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6643812 | 0.88 | GSK3A (0.57) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6305636 | 0.87 | MAPK14 (0.59) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6298778 | 0.86 | GSK3A (0.52) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6299751 | 0.85 | GSK3A (0.64) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6305403 | 0.85 | GSK3A (0.58) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6306257 | 0.84 | MAPK14 (0.62) | GSK3AMAPK14SRCSYKKDM4E | |
| SCHEMBL6304876 | 0.83 | MAPK14 (0.53) | GSK3AMAPK14SRCSYK | |
| SCHEMBL5623435 | 0.83 | GSK3A (0.51) | GSK3AMAPK14SRCSYKHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392661-A1 | DIARYLUREA DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002092576-A1 | DIARYLUREA DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2002-11-21 | — | — | WO | disclosed |