Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6645977 | 1.00 | GSK3B (0.37) | GSK3BPIK3R1PIK3CAADORA2AADORA1 | |
| SCHEMBL4872302 | 0.84 | GSK3B (0.35) | GSK3B | |
| SCHEMBL4870914 | 0.84 | GSK3B (0.37) | GSK3BPIK3R1PIK3CA | |
| SCHEMBL4870926 | 0.84 | GSK3B (0.37) | GSK3BPIK3R1PIK3CA | |
| SCHEMBL4870920 | 0.84 | GSK3B (0.37) | GSK3BPIK3R1PIK3CA | |
| Hydrochloric Acid SCHEMBL4869542 | 0.83 | GSK3B (0.35) | GSK3B | |
| SCHEMBL6675120 | 0.83 | GSK3B (0.46) | GSK3BPIK3R1PIK3CAADORA1 | |
| SCHEMBL6675118 | 0.83 | GSK3B (0.46) | GSK3BPIK3R1PIK3CAADORA1 | |
| SCHEMBL4865736 | 0.82 | GSK3B (0.48) | GSK3BPIK3R1PIK3CA | |
| SCHEMBL4870991 | 0.82 | GSK3B (0.51) | GSK3BPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430057-A2 | SUBSTITUTED 2-PYRIDINYL-6,7,8,9-TETRAHYDROPYRIMIDO 1,2-A]PYRIMIDIN-4-ONE AND 7-PYRIDINYL-2,3-DIHYDROIMIDAZO 1,2-A]PYRIMIDIN-5(1H)ONE DERIVATIVES | Sanofi-Aventis (FR) | 2004-06-23 | — | — | EP | claimed |
| WO-2003027116-A2 | SUBSTITUTED 2-PYRIDINYL-6,7,8,9-TETRAHYDROPYRIMIDO[1,2-A]PYRIMIDIN-4-ONE AND 7-PYRIDINYL-2,3-DIHYDROIMIDAZO[1,2-A]PYRIMIDIN-5(1H)ONE DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2003-04-03 | — | — | WO | claimed |