Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | DAO | P14920 | 2/20 | 0.47 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
| ▸ | CDC25C | P30307 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | DDO | Q99489 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6639980 | 0.87 | KDM4E (0.50) | PARP1KDM4ECDC25ACDC25CFEN1 | |
| SCHEMBL6069754 | 0.80 | MAPT (0.51) | PARP1LMNATNK2ALDH1A1MEN1 | |
| SCHEMBL6643842 | 0.80 | KDM4E (0.51) | PARP1KDM4EDAODDOLMNA | |
| SCHEMBL25919036 | 0.80 | PARP1 (0.42) | PARP1MEN1KMT2A | |
| SCHEMBL25153943 | 0.77 | KDM4E (0.48) | PARP1KDM4EDAODDOLMNA | |
| SCHEMBL6407884 | 0.77 | HSD17B10 (0.51) | PARP1LMNAALDH1A1TNKS2 | |
| SCHEMBL6408399 | 0.77 | PARP1 (0.57) | PARP1 | |
| SCHEMBL6648775 | 0.76 | PARP1 (0.58) | PARP1KDM4ELMNAHPGDTNK1 | |
| SCHEMBL25093566 | 0.76 | PARP1 (0.51) | PARP1 | |
| SCHEMBL6069756 | 0.76 | PARP1 (0.39) | PARP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054869-B1 | 3,4-DIHYDROQUINOLINE DERIVATIVES AS NITROGEN MONOXIDE SYNTHASE (NOS) INHIBITORS | SCHERING AG (DE) | 2004-09-22 | — | — | EP | disclosed |
| US-6391887-B1 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASE; CARDIOVASCULAR DISORDERS | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-05-21 | — | — | US | disclosed |