Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 9/20 | 0.53 |
| ▸ | FLT3 | P36888 | 7/20 | 0.53 |
| ▸ | FLT1 | P17948 | 7/20 | 0.53 |
| ▸ | LCK | P06239 | 6/20 | 0.53 |
| ▸ | RET | P07949 | 6/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.53 |
| ▸ | ABL1 | P00519 | 5/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.53 |
| ▸ | CSF1R | P07333 | 5/20 | 0.53 |
| ▸ | CLK2 | P49760 | 5/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.53 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.53 |
| ▸ | TAOK1 | Q7L7X3 | 5/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.53 |
| ▸ | MET | P08581 | 4/20 | 0.53 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7131259 | 0.88 | FLT1 (0.59) | KITFLT3FLT1LCKRET | |
| SCHEMBL6387113 | 0.86 | EPHB4 (0.48) | KITFLT3FLT1LCKRET | |
| SCHEMBL6647235 | 0.85 | KDR (0.51) | KITFLT3FLT1LCKRET | |
| SCHEMBL20816501 | 0.83 | FLT1 (0.62) | KITFLT3FLT1LCKRET | |
| SCHEMBL29923744 | 0.83 | FLT1 (0.62) | KITFLT3FLT1LCKRET | |
| SCHEMBL6090597 | 0.79 | KIT (0.52) | KITFLT3FLT1LCKRET | |
| SCHEMBL7070939 | 0.77 | KIT (0.50) | KITFLT3FLT1LCKRET | |
| SCHEMBL13372736 | 0.76 | KDR (0.60) | KITFLT3FLT1LCKRET | |
| SCHEMBL4469648 | 0.76 | KDR (0.78) | KITFLT3FLT1LCKRET | |
| SCHEMBL7070865 | 0.75 | KDR (0.52) | KITFLT3FLT1LCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487841-A1 | THIOPYRIMIDINE AND ISOTHIAZOLOPYRIMIDINE KINASE INHIBITORS | Abbott Laboratories (US) | 2004-12-22 | — | — | EP | claimed |
| WO-2003080625-A1 | THIOPYRIMIDINE AND ISOTHIAZOLOPYRIMIDINE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2003-10-02 | — | — | WO | claimed |
| US-20030225273-A1 | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors | ABBOTT LABORATORIES | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225273-A1 | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors | ABL1, ERBB2, LCK | KIT 394/4885FLT3 29/4885FLT1 337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.