Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.60 |
| ▸ | TAF1 | P21675 | 1/20 | 0.60 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | SALL4 | Q9UJQ4 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.43 |
| ▸ | TUBB | P07437 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5166372 | 0.99 | BRD4 (0.59) | BRD4TAF1TAF1LGAAMAPT | |
| SCHEMBL31193266 | 0.83 | BRD4 (0.66) | BRD4TAF1TAF1LGAAMAPT | |
| SCHEMBL14433728 | 0.80 | GAA (0.72) | BRD4TAF1TAF1LGAAMAPT | |
| SCHEMBL2924613 | 0.79 | GAA (0.70) | GAAMAPTTP53ALDH1A1KDM4E | |
| SCHEMBL20889310 | 0.75 | TRIM33 (0.65) | BRD4TAF1TAF1LGAAMAPT | |
| SCHEMBL16424677 | 0.75 | BRD4 (1.00) | BRD4TAF1TAF1L | |
| SCHEMBL20889436 | 0.74 | BRD4 (0.56) | BRD4TAF1TAF1LGAAMAPT | |
| SCHEMBL8160253 | 0.74 | BRD4 (0.55) | BRD4MAPTADRA1BALDH1A1TOP2A | |
| SCHEMBL31193303 | 0.74 | BRD4 (0.59) | BRD4TAF1TAF1LGAAMAPT | |
| SCHEMBL20889766 | 0.74 | BRD4 (0.55) | BRD4TAF1TAF1LGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326613-B1 | USE OF SUBSTITUTED IMIDAZO 1,2-A]PYRIDINE-, IMIDAZO [1,2-A]PYRIMIDINE AND IMIDAZO [1,2-A]PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2004-06-02 | — | — | EP | disclosed |